Distinct Cortical-Thalamic-Striatal Circuits through the Parafascicular Nucleus

Mandelbaum, G., Taranda, J., Haynes, T. M., Hochbaum, D. R., Huang, K. W., Hyun, M., Umadevi Venkataraju, K., Straub, C., Wang, W., Robertson, K., Osten, P., Sabatini, B. L. (March 2019) Distinct Cortical-Thalamic-Striatal Circuits through the Parafascicular Nucleus. Neuron, 102 (3). 636-652 e.. ISSN 0896-6273

URL: https://www.ncbi.nlm.nih.gov/pubmed/30905392
DOI: 10.1016/j.neuron.2019.02.035

Abstract

The thalamic parafascicular nucleus (PF), an excitatory input to the basal ganglia, is targeted with deep-brain stimulation to alleviate a range of neuropsychiatric symptoms. Furthermore, PF lesions disrupt the execution of correct motor actions in uncertain environments. Nevertheless, the circuitry of the PF and its contribution to action selection are poorly understood. We find that, in mice, PF has the highest density of striatum-projecting neurons among all sub-cortical structures. This projection arises from transcriptionally and physiologically distinct classes of PF neurons that are also reciprocally connected with functionally distinct cortical regions, differentially innervate striatal neurons, and are not synaptically connected in PF. Thus, mouse PF contains heterogeneous neurons that are organized into parallel and independent associative, limbic, and somatosensory circuits. Furthermore, these subcircuits share motifs of cortical-PF-cortical and cortical-PF-striatum organization that allow each PF subregion, via its precise connectivity with cortex, to coordinate diverse inputs to striatum.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > basal ganglia
Investigative techniques and equipment > electrophysiology
organs, tissues, organelles, cell types and functions > tissues types and functions > thalamus
CSHL Authors:
Communities: CSHL labs > Osten lab
Depositing User: Matthew Dunn
Date: 19 March 2019
Date Deposited: 28 Mar 2019 15:22
Last Modified: 29 May 2019 18:43
Related URLs:
URI: https://repository.cshl.edu/id/eprint/37765

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