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AltmetricWang, J. X., Furukawa, H. (January 2019) Dissecting diverse functions of NMDA receptors by structural biology. Curr Opin Struct Biol, 54. pp. 34-42. ISSN 0959-440x
Abstract
N-Methyl-d-aspartate receptors (NMDARs) are glutamate-gated ion channels, which are critically involved in brain development, learning and memory, cognition, as well as a number of neurological diseases and disorders. Structural biology of NMDARs has been challenging due to technical difficulties associated with assembling a number of different membrane protein subunits. Here, we review historical X-ray crystallographic studies on isolated extracellular domains, which are still the most effective mean to delineate compound binding modes, as well as the most recent studies using electron cryo-microscopy (cryo-EM). A number of NMDAR structures accumulated over the past 15 years provide insights into the hetero-tetrameric assembly pattern, pharmacological specificities elicited by subtypes and alternative splicing, and potential patterns of conformational dynamics; however, many more important unanswered questions remain.
| Item Type: | Paper |
|---|---|
| Subjects: | organs, tissues, organelles, cell types and functions > organs types and functions > brain bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > ion channel |
| CSHL Authors: | |
| Communities: | CSHL labs > Furukawa lab School of Biological Sciences > Publications |
| Depositing User: | Matthew Dunn |
| Date: | 28 January 2019 |
| Date Deposited: | 04 Feb 2019 20:55 |
| Last Modified: | 09 Sep 2021 18:36 |
| PMCID: | PMC6592722 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/37680 |
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