Structure, function, and allosteric modulation of NMDA receptors

Hansen, K. B., Yi, F., Perszyk, R. E., Furukawa, H., Wollmuth, L. P., Gibb, A. J., Traynelis, S. F. (July 2018) Structure, function, and allosteric modulation of NMDA receptors. J Gen Physiol. ISSN 0022-1295

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DOI: 10.1085/jgp.201812032


NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca(2+)-permeable component of excitatory neurotransmission in the central nervous system (CNS). They are expressed throughout the CNS and play key physiological roles in synaptic function, such as synaptic plasticity, learning, and memory. NMDA receptors are also implicated in the pathophysiology of several CNS disorders and more recently have been identified as a locus for disease-associated genomic variation. NMDA receptors exist as a diverse array of subtypes formed by variation in assembly of seven subunits (GluN1, GluN2A-D, and GluN3A-B) into tetrameric receptor complexes. These NMDA receptor subtypes show unique structural features that account for their distinct functional and pharmacological properties allowing precise tuning of their physiological roles. Here, we review the relationship between NMDA receptor structure and function with an emphasis on emerging atomic resolution structures, which begin to explain unique features of this receptor.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > NMDA receptor
bioinformatics > genomics and proteomics > small molecules > NMDA receptor
structural biology
CSHL Authors:
Communities: CSHL labs > Furukawa lab
Depositing User: Matthew Dunn
Date: 23 July 2018
Date Deposited: 26 Jul 2018 15:40
Last Modified: 08 Nov 2019 16:33
PMCID: PMC6080888
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