Stern, S., Tanaka, M., Herr, W. (October 1989) The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16. Nature, 341 (6243). pp. 624-30. ISSN 1476-4687
DOI: 10.1038/341624a0
Abstract
The herpes simplex virus transactivator VP16 participates in the formation of a multiprotein-DNA complex with the ubiquitous octamer-motif-binding factor Oct-1. Complex formation is dependent on specific amino acids in the Oct-1 homoeodomain which are in positions analogous to positive control mutations in helix 2 of the lambda phage repressor helix-turn-helix motif, indicating that this structure is an ancient target for protein-protein interactions mediating transcriptional control.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Amino Acid Sequence DNA-Binding Proteins/*metabolism/*physiology *Gene Expression Regulation, Viral *Genes, Homeobox Macromolecular Substances Molecular Sequence Data Multiprotein Complexes Phosphoproteins/*metabolism Protein Binding Protein Conformation Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Simplexvirus/*genetics Structure-Activity Relationship Trans-Activators/*metabolism Transcription Factors/*metabolism/*physiology/ultrastructure |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification organism description > virus > herpes simplex virus |
| CSHL Authors: | |
| Communities: | CSHL labs > Herr lab |
| Depositing User: | Gail Sherman |
| Date: | 19 October 1989 |
| Date Deposited: | 23 Jun 2017 19:28 |
| Last Modified: | 23 Jun 2017 19:28 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/34910 |
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