Nanopore sequencing meets epigenetics

Schatz, M. C. (March 2017) Nanopore sequencing meets epigenetics. Nat Methods, 14 (4). pp. 347-348. ISSN 1548-7091

DOI: 10.1038/nmeth.4240


Most DNA sequencing technologies cannot directly distinguish between methylated and unmethylated bases in native DNA. But a pair of papers1, 2 in this issue describe computational methods for doing just that using the Oxford Nanopore MinION sequencer. These advances make it possible to sequence this important regulatory mark without special sample preparation and, combined with the long-read single-molecule nature of the instrument, offer the potential to study allele-specific methylation in heterogeneous cancer samples and other important research settings.

Item Type: Paper
Subjects: bioinformatics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > epigenetics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > epigenetics
Investigative techniques and equipment > assays > next generation sequencing
CSHL Authors:
Communities: CSHL labs > Schatz lab
Depositing User: Matt Covey
Date: 31 March 2017
Date Deposited: 10 Apr 2017 20:51
Last Modified: 10 Apr 2017 20:51
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