Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer

Maki, R. G. (November 2010) Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer. J Clin Oncol, 28 (33). pp. 4985-95. ISSN 1527-7755 (Electronic)0732-183X (Linking)

DOI: 10.1200/JCO.2009.27.5040


Insulin-like growth factors were discovered more than 50 years ago as mediators of growth hormone that effect growth and differentiation of bone and skeletal muscle. Interest of the role of insulin-like growth factors in cancer reached a peak in the 1990s, and then waned until the availability in the past 5 years of monoclonal antibodies and small molecules that block the insulin-like growth factor 1 receptor. In this article, we review the history of insulin-like growth factors and their role in growth, development, organism survival, and in cancer, both epithelial cancers and sarcomas. Recent developments regarding phase I to II clinical trials of such agents are discussed, as well as potential studies to consider in the future, given the lack of efficacy of one such monoclonal antibody in combination with cytotoxic chemotherapy in a first-line study in metastatic non-small-cell lung adenocarcinoma. Greater success with these agents clinically is expected when combining the agents with inhibitors of other cell signaling pathways in which cross-resistance has been observed.

Item Type: Paper
Uncontrolled Keywords: Animals Clinical Trials as Topic *Growth Humans Insulin/physiology Insulin-Like Growth Factor Binding Proteins/physiology Longevity Neoplasms/*etiology Receptor, IGF Type 1/antagonists & inhibitors/physiology Sarcoma/etiology Signal Transduction Somatomedins/*physiology
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > IGF
organism description > animal > developmental stage
CSHL Authors:
Communities: CSHL labs > Maki lab
Depositing User: Matt Covey
Date: 20 November 2010
Date Deposited: 21 Oct 2016 20:07
Last Modified: 21 Oct 2016 20:07
PMCID: PMC3039924
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