Cardiac tumors and dysrhythmias in transgenic mice

Steinhelper, M. E., Field, L. J. (1990) Cardiac tumors and dysrhythmias in transgenic mice. Toxicol Pathol, 18 (4 Pt 1). pp. 464-9. ISSN 0192-6233 (Print)0192-6233 (Linking)



Transgenic mice expressing atrial natriuretic factor-SV40 T-antigen fusion genes (ANF-TAG) developed cardiac tumors asymmetrically in the right atrium. Features associated with cardiac failure, including increased plasma creatine kinase activity (MM and MB) and ventricular dysrhythmias, also were associated with atrial tumor growth. These atrial tumors were able to grow at histocompatible sites (subcutaneously in syngeneic animals) for protracted periods of time yielding a series of transplantable atrial tumor lineages. The transplantable tumors displayed several cardiac-specific characteristics, such as endogenous electrical activity and expression of cardiac-specific proteins. These transplantable atrial tumors constitute a novel experimental resource for developing cell lines which display an adult cardiac phenotype.

Item Type: Paper
Uncontrolled Keywords: Animals Antigens, Polyomavirus Transforming/genetics Arrhythmias, Cardiac/etiology/physiopathology Atrial Natriuretic Factor/genetics Cloning, Molecular Electrocardiography Female Heart/physiopathology Heart Atria/pathology Heart Neoplasms/complications/*genetics/pathology/physiopathology Mice Mice, Transgenic Neoplasm Transplantation Oncogenes/genetics
Subjects: diseases & disorders > cardiovascular diseases
organism description > animal > mammal > rodent > mouse
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > transgenic animal
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: 1990
Date Deposited: 05 Apr 2016 19:44
Last Modified: 05 Apr 2016 19:44

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