Direct measurement of quantal changes underlying long-term potentiation in CA1 hippocampus

Liao, D., Jones, A., Malinow, R. (December 1992) Direct measurement of quantal changes underlying long-term potentiation in CA1 hippocampus. Neuron, 9 (6). pp. 1089-97. ISSN 0896-6273 (Print)0896-6273 (Linking)

DOI: 10.1016/0896-6273(92)90068-O


The modification responsible for the long-term synaptic potentiation (LTP) that follows a brief conditioning period is not known. To elucidate this change, we have resolved quantal levels of transmission before and after induction of LTP. We find an increase both in the number of quanta released and in quantal amplitude, consistent with combined pre- and postsynaptic modifications. On average, about 60% of LTP can be accounted for by presynaptic enhancement. The increase in either quantal amplitude or quantal content varies significantly among different experiments, but is inversely correlated with its initial value. These results may help to reconcile the different views concerning the site of LTP expression.

Item Type: Paper
Uncontrolled Keywords: Animals Electric Stimulation Evoked Potentials Hippocampus/*physiology Neurons/physiology Probability Pyramidal Tracts/*physiology Quantum Theory Rats Synapses/*physiology Synaptic Transmission
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > Long term potentiation
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
CSHL Authors:
Depositing User: Matt Covey
Date: December 1992
Date Deposited: 23 Sep 2015 15:38
Last Modified: 23 Sep 2015 15:38
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