The development and imaging of advanced cancer models

Lyons, S. K. (February 2015) The development and imaging of advanced cancer models. Journal of Nuclear Medicine, 56 (2). p. 25. ISSN 0161-5505

DOI: 10.2967/jnm562abs


Mouse models of cancer provide an essential experimental link between fundamental discoveries made at the laboratory bench and the treatment of patients in the clinic. Advanced cancer models, in particular, whereby the expression of inherited genes can be both spatially and temporally regulated, comprise some of the most accurate phenocopies of the human disease currently available. From a practical standpoint, however, these models can be challenging to work with as tumors often develop at non-visible body locations and the timing of tumor onset can vary greatly with age. Effective non-invasive imaging can largely obviate these limitations and provide both anatomical and functional tumor-biology related information. The very nature of modelling cancer in the mouse is also changing, giving rise to exciting new experimental possibilities and far greater flexibility. Such modelling approaches also provide exciting new possibilities to non-invasively image tumor biology, in particular, with reporter transgenes, an experimental approach that can be employed to image a broad range of biological processes. Both modelling and imaging approaches will be discussed.

Item Type: Paper
Additional Information: Meeting Abstract
Subjects: diseases & disorders > cancer
Investigative techniques and equipment > imaging
Publication Type > Meeting Abstract
organism description > model organism
CSHL Authors:
Communities: CSHL labs > Lyons lab
Depositing User: Matt Covey
Date: 1 February 2015
Date Deposited: 11 Sep 2015 16:35
Last Modified: 06 Feb 2018 15:03

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