Soderling, S. H., Van Aelst, L. (2014) Principles driving the spatial organization of Rho GTPase signaling at synapses. In: Ras Superfamily Small G Proteins: Biology and Mechanisms 1: General Features, Signaling. Springer, pp. 395-419. ISBN 978-370911806-13709118050978-370911805-4S
Abstract
The Rho proteins play critical roles in numerous aspects of neuronal development, and mutations in their regulators (GEFs and GAPs) and effectors underlie multiple neurodevelopmental and neurological disorders. How Rho GTPase-mediated signaling can have a hand in regulating so many different neurobiological processes remains a challenging question. An emerging theme is that GAPs and GEFs, through their spatial/temporal regulation and/or through additional protein-protein interactions, cooperate in making connections between upstream signals and the downstream signaling output, engaging distinct effector proteins. This chapter focuses on recent evidence illustrating distinct modes of regulation and specialized roles of Rho regulators particularly in the context of synaptic structure, function, and plasticity, and how their dysregulation affects behavioral processes and contributes to disease. © 2014 Springer-Verlag Wien. All rights reserved.
| Item Type: | Book Section |
|---|---|
| Uncontrolled Keywords: | Brain disorders Neuronal development Rho effectors Rho regulators Synaptic structure and function |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > GTPase bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > G protein > Rho |
| CSHL Authors: | |
| Communities: | CSHL labs > Van Aelst lab |
| Depositing User: | Matt Covey |
| Date: | 2014 |
| Date Deposited: | 25 Jun 2015 16:05 |
| Last Modified: | 25 Jun 2015 16:05 |
| URI: | https://repository.cshl.edu/id/eprint/31599 |
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