Signal Transduction in Cancer

Sever, R., Brugge, J. S. (April 2015) Signal Transduction in Cancer. Cold Spring Harbor Perspectives in Medicine, 5 (4). ISSN 19430264

DOI: 10.1101/cshperspect.a006098


Cancer is driven by genetic and epigenetic alterations that allow cells to overproliferate and escape mechanisms that normally control their survival and migration. Many of these alterations map to signaling pathways that control cell growth and division, cell death, cell fate, and cell motility, and can be placed in the context of distortions of wider signaling networks that fuel cancer progression, such as changes in the tumor microenvironment, angiogenesis, and inflammation. Mutations that convert cellular proto-oncogenes to oncogenes can cause hyperactivation of these signaling pathways, whereas inactivation of tumor suppressors eliminates critical negative regulators of signaling. An examination of the PI3K-Akt and Ras-ERK pathways illustrates how such alterations dysregulate signaling in cancer and produce many of the characteristic features of tumor cells.

Item Type: Paper
Subjects: diseases & disorders > cancer
organs, tissues, organelles, cell types and functions > tissues types and functions > signal transduction
CSHL Authors:
Communities: CSHL Press
Depositing User: Matt Covey
Date: 1 April 2015
Date Deposited: 17 Apr 2015 14:38
Last Modified: 16 Jul 2021 13:19
PMCID: PMC4382731
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