Reconstructing the Evolutionary History of Complex Human Gene Clusters

Zhang, Yu, Song, Giltae, Vinar, Tomas, Green, EricD, Siepel, Adam, Miller, Webb (2008) Reconstructing the Evolutionary History of Complex Human Gene Clusters. In: Research in Computational Molecular Biology. Lecture Notes in Computer Science, 4955 . Springer Berlin Heidelberg, pp. 29-49. ISBN 978-3-540-78838-6

DOI: 10.1007/978-3-540-78839-3_4


Clusters of genes that evolved from single progenitors via repeated segmental duplications present significant challenges to the generation of a truly complete human genome sequence. Such clusters can confound both accurate sequence assembly and downstream computational analysis, yet they represent a hotbed of functional innovation, making them of extreme interest. We have developed an algorithm for reconstructing the evolutionary history of gene clusters using only human genomic sequence data. This method allows the tempo of large-scale evolutionary events in human gene clusters to be estimated, which in turn will facilitate primate comparative sequencing studies that will aim to reconstruct their evolutionary history more fully.

Item Type: Book Section
Subjects: bioinformatics
bioinformatics > computational biology
CSHL Authors:
Communities: CSHL labs > Siepel lab
Depositing User: Matt Covey
Date: 2008
Date Deposited: 15 Jan 2015 20:53
Last Modified: 15 Jan 2015 20:53

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