Xu, Y., Vakoc, C. R. (November 2014) Brd4 is on the move during inflammation. Trends in Cell Biology, 24 (11). pp. 615-616. ISSN 0962-8924
Abstract
Enhancer landscapes are shaped by the integrated functions of lineage-specific and signal-dependent transcription factors. A new study by Brown et al. suggests that the signal-dependent transcription factor NF-kB can modulate global enhancer activities by altering the occupancy of Brd4, a BET bromodomain coactivator protein, across the genome. This work reveals new principles of enhancer dynamics and insights into the therapeutic modulation of enhancer function with BET bromodomain inhibitors.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Brd4 p65 NF-kB enhancer super-enhancer inflammation JQ1 BET bromodomain |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > BET bromodomain coactivator protein bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > BET bromodomain coactivator protein > Brd4 diseases & disorders > inflammation bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > NF-kappaB |
| CSHL Authors: | |
| Communities: | CSHL labs > Vakoc lab |
| Depositing User: | Matt Covey |
| Date: | November 2014 |
| Date Deposited: | 09 Oct 2014 18:50 |
| Last Modified: | 24 Apr 2015 18:43 |
| PMCID: | PMC4252248 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/30831 |
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