The transcription factor Foxo1 controls central-memory CD8+ T cell responses to infection

Kim, M. V., Ouyang, W., Liao, W., Zhang, M. Q., Li, M. O. (August 2013) The transcription factor Foxo1 controls central-memory CD8+ T cell responses to infection. Immunity, 39 (2). pp. 286-97. ISSN 1074-7613

Abstract

Memory T cells protect hosts from pathogen reinfection, but how these cells emerge from a pool of antigen-experienced T cells is unclear. Here, we show that mice lacking the transcription factor Foxo1 in activated CD8+ T cells have defective secondary, but not primary, responses to Listeria monocytogenes infection. Compared to short-lived effector T cells, memory-precursor T cells expressed higher amounts of Foxo1, which promoted their generation and maintenance. Chromatin immunoprecipitation sequencing revealed the transcription factor Tcf7 and the chemokine receptor Ccr7 as Foxo1-bound target genes, which have critical functions in central-memory T cell differentiation and trafficking. These findings demonstrate that Foxo1 is selectively incorporated into the genetic program that regulates memory CD8+ T cell responses to infection.

Item Type:	Paper
Uncontrolled Keywords:	Adoptive Transfer Animals Bone Marrow Cells CD8-Positive T-Lymphocytes/*immunology/metabolism Cell Differentiation Forkhead Transcription Factors/deficiency/genetics/*metabolism Green Fluorescent Proteins/genetics Immunologic Memory/*immunology Listeria monocytogenes/immunology Listeriosis/immunology Lymphocyte Activation/immunology Mice Mice, Inbred C57BL Mice, Transgenic Receptors, CCR7/*metabolism T Cell Transcription Factor 1/*metabolism
Subjects:	diseases & disorders > Bacterial Infections organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > immune cell organs, tissues, organelles, cell types and functions > cell types and functions > cell types > immune cell organs, tissues, organelles, cell types and functions > cell types and functions > cell types > immune cell bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor
CSHL Authors:	Liao, Will
Communities:	CSHL labs > Atwal lab
Depositing User:	Matt Covey
Date:	22 August 2013
Date Deposited:	07 Mar 2014 16:38
Last Modified:	14 Mar 2014 13:37
PMCID:	PMC3809840
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/29566

Actions (login required)

Administrator's edit/view item