Recombination in telomere-length maintenance

Kass-Eisler, A., Greider, C. W. (April 2000) Recombination in telomere-length maintenance. Trends in Biochemical Sciences, 25 (4). pp. 200-206. ISSN 0968-0004

Abstract

Although telomerase is the major mechanism for telomere elongation in most cells, telomerase-independent mechanisms of telomere maintenance can allow cell survival. Yeast cells that lack telomerase maintain telomere length through a form of recombination known as gene conversion. Understanding the role that telomeric recombination might play in mammalian cells has important implications for cancer therapeutics.

Item Type:	Paper
Uncontrolled Keywords:	IMMORTAL HUMAN-CELLS SACCHAROMYCES-CEREVISIAE DNA-SEQUENCES YEAST KU LACKING TELOMERASE WILD-TYPE SENESCENCE IDENTIFICATION ORGANIZATION MECHANISM
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > recombination bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > telomerase bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > telomeres organism description > yeast
CSHL Authors:	Greider, Carol Kass-Eisler, Alyson
Communities:	CSHL labs
Depositing User:	Matt Covey
Date:	April 2000
Date Deposited:	28 Jan 2014 20:17
Last Modified:	28 Jan 2014 20:17
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/29439

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