Stein, L. D. (May 2001) Genetic analyses on DNA microarrays. Curr Protoc Hum Genet, Chapte. Unit 11 .01.
Abstract
A great stir has coursed through the genetics community with the advent in 1996 of "chip technologies," a series of related techniques that allow DNA hybridization-based studies to be performed with unprecedented speed and parallelism. All chip technologies have in common a microarray, a small glass chip approximately one square centimeter in area, to which nucleotide sequences are bound. Fluorescently labeled nucleic acids are hybridized to the microarray and imaged with a laser scanner or fluorescence microscope. This unit offers an overview of the two dominant technologies, cDNA microarrays and oligonucleotide chips. It concludes with a discussion regarding how well microarrays perform real-world expression analysis.
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics > genomics and proteomics > Mapping and Rendering > Micro Array Data Rendering bioinformatics > genomics and proteomics > analysis and processing > microarray gene expression processing |
| CSHL Authors: | |
| Communities: | CSHL labs > Stein lab |
| Depositing User: | Matt Covey |
| Date: | May 2001 |
| Date Deposited: | 16 Jan 2014 17:28 |
| Last Modified: | 16 Jan 2014 17:28 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/29309 |
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