Tasdemir, N., Lowe, S. W. (June 2013) Senescent cells spread the word: non-cell autonomous propagation of cellular senescence. Embo Journal, 84 (1). pp. 114-127. ISSN 0261-4189
Abstract
Senescence has long been considered a cell autonomous arrest programme restricting the propagation of damaged cells in tissues. Now there is accumulating evidence that senescent cells can communicate with their environment. In a recent report by Gil and colleagues (Acosta et al, 2013), it now seems senescence can be transmitted in a paracrine fashion in several in vitro and in vivo contexts. In addition to broadening our understanding of the biology of senescence, these new findings may have interesting implications for tissue homeostasis and future cancer therapies.
| Item Type: | Paper |
|---|---|
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell functions organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > senescence |
| CSHL Authors: | |
| Communities: | CSHL labs > Lowe lab School of Biological Sciences > Publications |
| Depositing User: | Matt Covey |
| Date: | 18 June 2013 |
| Date Deposited: | 28 Jun 2013 14:11 |
| Last Modified: | 19 Jul 2021 15:17 |
| PMCID: | PMC3715860 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/28380 |
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