Cell fusion: a hidden enemy?

Duelli, Dominik, Lazebnik, Yuri (2003) Cell fusion: a hidden enemy? Cancer Cell, 3 (5). pp. 445-448. ISSN 1535-6108

URL: http://www.ncbi.nlm.nih.gov/pubmed/12781362
DOI: 10.1016/S1535-6108(03)00114-4


The recent findings that cell fusion may be involved in stem cell differentiation (Medvinsky and Smith, 2003) raise a possibility that cell fusion has undiscovered functions, some of which can perhaps be found by revisiting the old ideas that cell fusion can promote disease, especially cancer. Cell fusion is a process in which two or more cells become one by merging their plasma membranes. The ability of a cell to fuse to other cells is referred to as fusogenicity. The progeny of cell fusion are known as hybrids. Perhaps the best-known hybrids are hybridomas, which are made by fusing myeloma cells with lymphocytes to produce monoclonal antibodies. Although cells can be easily fused in the laboratory using readily available chemicals, cell fusion in live organisms appears to be a complex, poorly understood, multistep process that involves cell-cell recognition, cell adhesion, and membrane fusion (reviewed in Hernandez et al., 1996).

Item Type: Paper
Uncontrolled Keywords: Animals Cell Differentiation Cell Fusion Cell Line, Transformed Chromosome Aberrations Drug Resistance, Neoplasm Humans Neoplasm Metastasis Neoplasms
Subjects: Investigative techniques and equipment > cell fusion
CSHL Authors:
Communities: CSHL labs > Labeznik lab
Depositing User: Matt Covey
Date: 2003
Date Deposited: 12 Dec 2012 17:30
Last Modified: 12 Dec 2012 17:30
Related URLs:
URI: https://repository.cshl.edu/id/eprint/26377

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