Chemical signaling among bacteria and its inhibition

Lyon, Gholson J., Muir, Tom W. (2003) Chemical signaling among bacteria and its inhibition. Chemistry & Biology, 10 (11). pp. 1007-1021. ISSN 1074-5521

DOI: 10.1016/j.chembiol.2003.11.003


Generations of chemists and biologists have conducted research on natural products and other metabolites produced by bacteria and other microorganisms. This has led to an explosion in knowledge concerning the mechanism by which such natural products are made, ultimately allowing custom redesign of many of these molecules for increased potency and selectivity as therapeutic drugs. Along the way, scientists have begun to appreciate that the bacterial world is teeming with life on a scale hardly conceivable, with constant communication within the bacterial world and with outside neighbors, such as plants and mammals. Only in recent years have some of the signaling molecules that comprise these elaborate forms of communication been characterized in any sort of chemical detail, which has in turn peaked interest in the intricate biology of this micro-world and its interactions with the macro-world.

Item Type: Paper
Uncontrolled Keywords: Bacteria Bacterial Physiological Phenomena Signal Transduction Species Specificity
Subjects: organism description > bacteria
CSHL Authors:
Communities: CSHL labs > Lyon lab
Depositing User: Matt Covey
Date: 2003
Date Deposited: 10 Dec 2012 20:12
Last Modified: 10 Dec 2012 21:23

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