Chromosome evolution in eukaryotes: a multi-kingdom perspective

Coghlan, A., Eichler, E. E., Oliver, S. G., Paterson, A. H., Stein, L. D. (December 2005) Chromosome evolution in eukaryotes: a multi-kingdom perspective. Trends in Genetics, 21 (12). pp. 673-682. ISSN 0168-9525

DOI: 10.1016/j.tig.2005.09.009


In eukaryotes, chromosomal rearrangements, such as inversions, translocations and duplications, are common and range from part of a gene to hundreds of genes. Lineage-specific patterns are also seen: translocations are rare in dipteran flies, and angiosperm genomes seem prone to polyploidization. In most eukaryotes, there is a strong association between rearrangement breakpoints and repeat sequences. Current data suggest that some repeats promoted rearrangements via non-allelic homologous recombination, for others the association might not be causal but reflects the instability of particular genomic regions. Rearrangement polymorphisms in eukaryotes are correlated with phenotypic differences, so are thought to confer varying fitness in different habitats. Some seem to be under positive selection because they either trap favorable allele combinations together or alter the expression of nearby genes. There is little evidence that chromosomal rearrangements cause speciation, but they probably intensify reproductive isolation between species that have formed by another route.

Item Type: Paper
Uncontrolled Keywords: ANOPHELES-GAMBIAE COMPLEX anopheles-gambiae complex Anopheles Gambiae complex WIDESPREAD DROSOPHILA INVERSION widespread Drosophila Inversion COMPARATIVE SEQUENCE-ANALYSIS sequence analysis DETAILED RFLP MAP detailed RFLP map APPLE MAGGOT FLY Apple Maggot fly SACCHAROMYCES-CEREVISIAE Saccharomyces Cerevisiae HUMAN GENOME human genome MOLECULAR CHARACTERIZATION molecular characterization SEGMENTAL DUPLICATIONS segmental duplications TRANSPOSABLE ELEMENT transposable element
Subjects: bioinformatics > genomics and proteomics > annotation > map annotation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function
CSHL Authors:
Communities: CSHL labs > Stein lab
Depositing User: CSHL Librarian
Date: December 2005
Date Deposited: 13 Jan 2012 20:09
Last Modified: 03 May 2018 14:40
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