Rapid arrival and integration of ascending sensory information in layer 1 nonpyramidal neurons and tuft dendrites of layer 5 pyramidal neurons of the neocortex

Zhu, Y. H., Zhu, J. J. (February 2004) Rapid arrival and integration of ascending sensory information in layer 1 nonpyramidal neurons and tuft dendrites of layer 5 pyramidal neurons of the neocortex. Journal of Neuroscience, 24 (6). pp. 1272-1279. ISSN 0270-6474

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DOI: 10.1523/JNEUROSCI.4805-03.2004

Abstract

Ascending sensory inputs arriving in layer 1 of the neocortex carry crucial signals for detecting salient information; but how the inputs are processed in layer 1 is unknown. Using a whole-cell in vivo recording technique targeting nonpyramidal neurons in layer 1 and tuft dendrites of layer 5 pyramidal neurons in layers 1 - 2, we examined the processing of these ascending sensory inputs in the barrel cortex. Here, we show that local circuit and deeper-layer-projecting neurons in layer 1, as well as tuft dendrites and somata of layer 5 pyramidal neurons, respond to multiple whiskers ( 6 - 15) with robust EPSPs. Remarkably, the latency for primary whisker-evoked responses is as short as similar to 5 - 7 msec in layer 1 neurons and tuft dendrites of layer 5 pyramidal neurons. In addition, the latency for primary whisker-evoked responses in tuft dendrites of layer 5 pyramidal neurons is similar to 1 msec shorter than that in somata. These results indicate that ascending sensory inputs arrive in layers 1 and 4 concurrently, which provides a neural mechanism for rapid integration and coincident detection of salient sensory information.

Item Type: Paper
Uncontrolled Keywords: rat somatosensory excitation inhibition whisker attention LATERAL GENICULATE-NUCLEUS primary geniculate nucleus PRIMARY SOMATOSENSORY CORTEX primary somatosensory cortex RAT BARREL rat barrel cortex CORTEX RECEPTIVE-FIELDS receptive fields VISUAL-CORTEX visual cortex IN-VIVO in-vovo THALAMOCORTICAL thalamocortical PROJECTIONS projections GABAERGIC INTERNEURONS GABAergic internurons POSTNATAL-DEVELOPMENT postnatal devlopment SYNAPTIC synaptic PHYSIOLOGY
Subjects: Investigative techniques and equipment > electrophysiology
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons
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Depositing User: CSHL Librarian
Date: February 2004
Date Deposited: 17 Jan 2012 15:03
Last Modified: 20 Apr 2012 20:25
URI: https://repository.cshl.edu/id/eprint/22526

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