Chandelier cells control excessive cortical excitation: Characteristics of whisker-evoked synaptic responses of layer 2/3 nonpyramidal and pyramidal neurons

Zhu, Y. H., Stornetta, R. L., Zhu, J. J. (June 2004) Chandelier cells control excessive cortical excitation: Characteristics of whisker-evoked synaptic responses of layer 2/3 nonpyramidal and pyramidal neurons. Journal of Neuroscience, 24 (22). pp. 5101-5108. ISSN 0270-6474

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URL: http://www.jneurosci.org/content/24/22/5101.full.p...
DOI: 10.1523/​JNEUROSCI.0544-04.2004

Abstract

Chandelier cells form inhibitory axo-axonic synapses on pyramidal neurons with their characteristic candlestick-like axonal terminals. The functional role of chandelier cells is still unclear, although the preferential loss of this cell type at epileptic loci suggests a role in epilepsy. Here we report an examination of whisker-and spontaneous activity-evoked responses in chandelier cells and other fast-spiking nonpyramidal neurons and regular-spiking pyramidal neurons in layer 2/3 of the barrel cortex. Fast-spiking nonpyramidal neurons, including chandelier cells, basket cells, neurogliaform cells, double bouquet cells, net basket cells, bitufted cells, and regular-spiking pyramidal neurons all respond to stimulation of multiple whiskers on the contralateral face. Whisker stimulation, however, evokes small, delayed EPSPs preceded by an earlier IPSP and no action potentials in chandelier cells, different from other nonpyramidal and pyramidal neurons. In addition, chandelier cells display a larger receptive field with lower acuity than other fast-spiking nonpyramidal neurons and pyramidal neurons. Notably, simultaneous dual whole-cell in vivo recordings show that chandelier cells, which rarely fire action potentials spontaneously, fire more robustly than other types of cortical neurons when the overall cortical excitation increases. Thus, chandelier cells may not process fast ascending sensory information but instead may be reserved to prevent excessive excitatory activity in neuronal networks.

Item Type: Paper
Uncontrolled Keywords: rat somatosensory excitation inhibition whisker epilepsy RAT BARREL CORTEX rat barrel cortex INHIBITORY POSTSYNAPTIC POTENTIALS inhibitory postsynaptic potentials PRIMARY SOMATOSENSORY CORTEX somatosensory cortex LATERAL GENICULATE-NUCLEUS lateral genitulate nucleus INTRINSIC FIRING intrinsic firing PATTERNS RECEPTIVE-FIELDS receptive fields IN-VIVO in-vivo GABAERGIC INTERNEURONS GABAergic interneurons DENDRITIC dendritic MECHANISMS MYSTACIAL VIBRISSAE mystacial vibrissae
Subjects: diseases & disorders > nervous system diseases and disorders > epilepsy
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons
CSHL Authors:
Depositing User: CSHL Librarian
Date: June 2004
Date Deposited: 17 Jan 2012 14:54
Last Modified: 17 Jan 2012 14:54
URI: https://repository.cshl.edu/id/eprint/22525

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