Genetic approaches identify adult pituitary stem cells

Gleiberman, A. S., Michurina, T. V., Encinas, J. M., Roig, J. L., Krasnov, P., Balordi, F., Fishell, G., Rosenfeld, M. G., Enikolopov, G. N. (2008) Genetic approaches identify adult pituitary stem cells. Proc Natl Acad Sci U S A, 105 (17). pp. 6332-7.

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URL: https://www.ncbi.nlm.nih.gov/pubmed/18436641
DOI: 10.1073/pnas.0801644105

Abstract

Adult tissues undergo continuous cell turnover in response to stress, damage, or physiological demand. New differentiated cells are generated from dedicated or facultative stem cells or from self-renewing differentiated cells. Here we describe a different stem cell strategy for tissue maintenance, distinct from that observed for dedicated or facultative stem cells. We report the presence of nestin-expressing adult stem cells in the perilumenal region of the mature anterior pituitary and, using genetic inducible fate mapping, demonstrate that they serve to generate subsets of all six terminally differentiated endocrine cell types of the pituitary gland. These stem cells, while not playing a significant role in organogenesis, undergo postnatal expansion and start producing differentiated progeny, which colonize the organ that initially entirely consisted of differentiated cells derived from embryonic precursors. This generates a mosaic organ with two phenotypically similar subsets of endocrine cells that have different origins and different life histories. These parallel but distinct lineages of differentiated cells in the gland may help the maturing organism adapt to changes in the metabolic regulatory landscape.

Item Type: Paper
Uncontrolled Keywords: Adult Stem Cells/*cytology/metabolism Animals Cell Differentiation Cell Lineage Cell Proliferation Green Fluorescent Proteins/metabolism Intermediate Filament Proteins/metabolism Mice Mice, Inbred C57BL Models, Biological Nerve Tissue Proteins/metabolism Pituitary Gland, Anterior/*cytology Pituitary Neoplasms/pathology
Subjects: therapies > stem cells > Adult
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > germ cell > Adult
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > germ cell > Adult
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > germ cell > Adult
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > Adult
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > Adult
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > Adult
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > Adult
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > Adult
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > Adult

diseases & disorders > endocrine system diseases
diseases & disorders > neoplasms
?? Q1 ??
therapies > stem cells
CSHL Authors:
Communities: CSHL labs > Enikopolov lab
Depositing User: Tom Adams
Date Deposited: 11 Jul 2011 15:00
Last Modified: 28 Feb 2017 21:33
PMCID: PMC2359820
Related URLs:
URI: http://repository.cshl.edu/id/eprint/7746

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