Cellular and Molecular Immune Response to Chikungunya Virus Infection

Tanabe, I. S. B., Tanabe, E. L. L., Santos, E. C., Martins, W. V., Araujo, Imtc, Cavalcante, M. C. A., Lima, A. R. V., Camara, N. O. S., Anderson, L., Yunusov, D., Bassi, E. J. (October 2018) Cellular and Molecular Immune Response to Chikungunya Virus Infection. Frontiers in Cellular and Infection Microbiology, 8. Article no: 345. ISSN 2235-2988

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URL: https://www.ncbi.nlm.nih.gov/pubmed/30364124
DOI: 10.3389/fcimb.2018.00345

Abstract

Chikungunya virus (CHIKV) is a re-emergent arthropod-borne virus (arbovirus) that causes a disease characterized primarily by fever, rash and severe persistent polyarthralgia. In the last decade, CHIKV has become a serious public health problem causing several outbreaks around the world. Despite the fact that CHIKV has been around since 1952, our knowledge about immunopathology, innate and adaptive immune response involved in this infectious disease is incomplete. In this review, we provide an updated summary of the current knowledge about immune response to CHIKV and about soluble immunological markers associated with the morbidity, prognosis and chronicity of this arbovirus disease. In addition, we discuss the progress in the research of new vaccines for preventing CHIKV infection and the use of monoclonal antibodies as a promising therapeutic strategy.

Item Type: Paper
Subjects: diseases & disorders > viral diseases
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > monoclonal antibody
CSHL Authors:
Communities: CSHL labs > Gingeras lab
Depositing User: Matthew Dunn
Date: 10 October 2018
Date Deposited: 01 Nov 2018 18:55
Last Modified: 01 Nov 2018 18:55
PMCID: PMC6191487
Related URLs:
URI: http://repository.cshl.edu/id/eprint/37266

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