Production of mitotic abnormalities by ethylenediaminetetraacetic acid

McDonald, M. R., Kaufmann, B. P. (April 1957) Production of mitotic abnormalities by ethylenediaminetetraacetic acid. Exp Cell Res, 12 (2). pp. 415-7. ISSN 0014-4827 (Print)0014-4827 (Linking)

URL: https://www.ncbi.nlm.nih.gov/pubmed/13414806
DOI: 10.1016/0014-4827(57)90159-3

Abstract

Treatment of growing roots of onion with solutions of EDTA between 0.0004 and 0.002 M was found to modify the form and distribution of the chromosomes of the meristematic cells. Similar results were obtained with 0.002 M CaCl2 or MgCl2. The effects of EDTA are attributed to alterations in the general metabolism of the cell, rather than to direct breakage of chromosomes through chelation of divalent cations serving as bridges between macromolecular complexes of protein and nucleic acids.

Item Type: Paper
Uncontrolled Keywords: Cell Division/*drug effects Edetic Acid/*pharmacology *CELL DIVISION/effect of drugs on *EDATHAMIL/effects
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell division
organs, tissues, organelles, cell types and functions > organelles, types and functions > mitosis
CSHL Authors:
Communities: The Carnegie Institution Department of Genetics
Depositing User: Matt Covey
Date: April 1957
Date Deposited: 22 Jan 2018 20:36
Last Modified: 22 Jan 2018 20:36
Related URLs:
URI: http://repository.cshl.edu/id/eprint/35964

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