Consumptive coagulopathy in angiosarcoma: a recurrent phenomenon?

Farid, M., Ahn, L., Brohl, A., Cioffi, A., Maki, R. G. (2014) Consumptive coagulopathy in angiosarcoma: a recurrent phenomenon? Sarcoma, 2014. p. 617102. ISSN 1357-714X (Print)1357-714X (Linking)

URL: https://www.ncbi.nlm.nih.gov/pubmed/24693222
DOI: 10.1155/2014/617102

Abstract

Objectives. To report the prevalence of consumptive coagulopathy in angiosarcoma patients seen at a single center. Methods. We retrospectively reviewed case records of 42 patients diagnosed with angiosarcoma at Mount Sinai Hospital between 2000 and 2013. Results. Seven patients (17%) met clinical criteria for disseminated intravascular coagulation (DIC) in absence of concomitant clinical states known to cause coagulopathy or myelosuppression. In all patients who received systemic antineoplastic therapy with resultant disease response or stability, DIC resolved in tandem with clinical improvement. DIC recurred at time of disease progression in all cases. Two patients had bulky disease, defined as diameter of largest single or contiguous tumor mass measuring 5 cm or more. All patients demonstrated an aggressive clinical course with short duration of disease control and demise within 1 year. In contrast, evaluation over the same period of 17 epithelioid hemangioendothelioma patients serving as a clinical control group revealed no evidence of DIC. Conclusion. Angiosarcomas can be associated with a consumptive coagulopathy arising in tandem with disease activity. Vigilance for this complication will be needed in the course of often aggressive multimodality therapy. The potential utility of coagulopathy as a prognostic biomarker will need to be explored in future studies.

Item Type: Paper
Subjects: diseases & disorders > cancer
diseases & disorders > cancer > cancer types > angiosarcoma
diseases & disorders > cancer > prognosis
CSHL Authors:
Communities: CSHL labs > Maki lab
Depositing User: Matt Covey
Date: 2014
Date Deposited: 20 Oct 2016 14:12
Last Modified: 20 Oct 2016 14:12
PMCID: PMC3945465
Related URLs:
URI: http://repository.cshl.edu/id/eprint/33761

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