The low molecular weight of RNAs of adenovirus 2-infected cells

Mathews, M. B., Pettersson, U. (February 1978) The low molecular weight of RNAs of adenovirus 2-infected cells. J Mol Biol, 119 (2). pp. 293-328. ISSN 0022-2836 (Print)0022-2836 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/633371
DOI: 10.1016/0022-2836(78)90439-4

Abstract

The cytoplasm of HeLa cells infected with adenovirus type 2 contains many species of low molecular weight RNA, including several of viral origin. In addition to a 9 S messenger RNA, the viral genome gives rise to two species of virus-associated RNA: the major species is 5.5 S RNA or virus-associated RNAI, and the minor species is 5.2 S RNA or virus-associated RNAII. Virus-associated RNAI occurs in the cytoplasm in several electrophoretically separable forms, and its sequences are also present in high molecular weight nuclear RNA but not in cytoplasmic mRNA. The structure of virus-associated RNAII is shown to be distinct from that of the major species, and the position of its gene is mapped on the viral genome. The two virus-associated RNA genes are located on the r strand near position 30 of the adenovirus type 2 physical map, and are separated by a spacer of about 75 base-pairs.

Item Type: Paper
Uncontrolled Keywords: *Adenoviridae Base Sequence Chromosome Mapping Cytoplasm/analysis Electrophoresis, Paper HeLa Cells Molecular Weight Nucleic Acid Hybridization *RNA/analysis RNA, Viral/analysis
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNA expression
organism description > virus > adenovirus
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: 25 February 1978
Date Deposited: 24 Aug 2016 20:36
Last Modified: 24 Aug 2016 20:36
Related URLs:
URI: http://repository.cshl.edu/id/eprint/33334

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