RNA transcription and splicing at early and intermediate times after adenovirus-2 infection

Chow, L. T., Lewis, J. B., Broker, T. R. (1980) RNA transcription and splicing at early and intermediate times after adenovirus-2 infection. Cold Spring Harb Symp Quant Biol, 44 (1). pp. 401-414.

URL: http://www.ncbi.nlm.nih.gov/pubmed/6933037
DOI: 10.1101/SQB.1980.044.01.044

Abstract

Transcription of human adenovirus-2 (Ad2) DNA1 has generally been recognized to have an early phase (from 1 to 8 hours after infection of permissive human cells) and a late phase, essentially coincident with DNA replication (from 8 hours until cell death at 48–72 hours after infection). Solution-hybridization studies have shown that about one fourth of the genome is expressed as cytoplasmic RNA at early times after infection and that these RNAs come from four widely separated regions, two on each DNA strand (Green et al. 1971; Sharp et al. 1975; Pettersson et al. 1976). Electron microscopic studies of R loops formed with early Ad2 RNA in double-stranded Ad2 DNA (Chow et al. 1977b; Westphal and Lai 1977) as well as nuclease-S1 mapping of RNA-single-stranded-DNA heteroduplexes (Berk and Sharp 1977b) produced evidence that early region 1 is subdivided into two segments, 1A and 1B.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription
organism description > virus > adenovirus
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNA splicing
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: 1980
Date Deposited: 02 Jun 2016 15:19
Last Modified: 02 Jun 2016 15:19
Related URLs:
URI: http://repository.cshl.edu/id/eprint/32673

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