Cell migration in the developing rodent olfactory system

Huilgol, D., Tole, S. (2016) Cell migration in the developing rodent olfactory system. Cell Mol Life Sci, 73 (13). pp. 2467-2490. ISSN 1420-9071 (Electronic)1420-682X (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/26994098
DOI: 10.1007/s00018-016-2172-7

Abstract

The components of the nervous system are assembled in development by the process of cell migration. Although the principles of cell migration are conserved throughout the brain, different subsystems may predominantly utilize specific migratory mechanisms, or may display unusual features during migration. Examining these subsystems offers not only the potential for insights into the development of the system, but may also help in understanding disorders arising from aberrant cell migration. The olfactory system is an ancient sensory circuit that is essential for the survival and reproduction of a species. The organization of this circuit displays many evolutionarily conserved features in vertebrates, including molecular mechanisms and complex migratory pathways. In this review, we describe the elaborate migrations that populate each component of the olfactory system in rodents and compare them with those described in the well-studied neocortex. Understanding how the components of the olfactory system are assembled will not only shed light on the etiology of olfactory and sexual disorders, but will also offer insights into how conserved migratory mechanisms may have shaped the evolution of the brain.

Item Type: Paper
Uncontrolled Keywords: Domains Evolution Migration Neocortex Olfactory Vomeronasal
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell migration
neurobiology
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neurogenesis
organs, tissues, organelles, cell types and functions > tissues types and functions > olfactory bulb
CSHL Authors:
Communities: CSHL labs > Huang lab
Depositing User: Matt Covey
Date Deposited: 22 Mar 2016 14:52
Last Modified: 08 Jul 2016 20:55
PMCID: PMC4894936
Related URLs:
URI: http://repository.cshl.edu/id/eprint/32452

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