Determinants of the B-cell response against a transgenic autoantigen

Skowronski, J., Jolicoeur, C., Alpert, S., Hanahan, D. (October 1990) Determinants of the B-cell response against a transgenic autoantigen. Proc Natl Acad Sci U S A, 87 (19). pp. 7487-91. ISSN 0027-8424 (Print)0027-8424 (Linking)

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URL: http://www.ncbi.nlm.nih.gov/pubmed/2217180

Abstract

The failure to induce self-tolerance of simian virus 40 large tumor antigen (T antigen) expressed in the pancreatic beta cells of transgenic mice results in an autoimmune response against this protein and the cells that synthesize it. In every transgenic mouse with delayed onset of T-antigen expression and consequent nontolerance, B cells, T cells, and macrophages are attracted to and infiltrate the pancreatic islets. In contrast, the incidence, onset, and intensity of the B-cell response to produce anti-T-antigen autoantibodies vary considerably with genetic background. Thus the initial attraction of lymphocytes to the cells synthesizing a non-self antigen can be separated from the activation of a B-cell response against it. Haplotypes of the major histocompatibility complex (MHC) differentially influence the character of the autoimmune response, with H-2d and H-2k conferring a high incidence of humoral autoimmunity. Additional non-MHC linked genes are also implicated in control of the B-cell response.

Item Type: Paper
Uncontrolled Keywords: Animals *Antibody Formation Autoantibodies/analysis Autoantigens/genetics/*immunology B-Lymphocytes/*immunology Crosses, Genetic H-2 Antigens/genetics/immunology Haplotypes Islets of Langerhans/immunology Major Histocompatibility Complex Mice Mice, Inbred Strains Mice, Transgenic Restriction Mapping T-Lymphocytes/immunology
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > B cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > B cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > B cells

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > major histocompatibility complex
organism description > virus
CSHL Authors:
Communities: CSHL labs > Skowronski lab
Depositing User: Matt Covey
Date: October 1990
Date Deposited: 04 Apr 2016 19:58
Last Modified: 09 Nov 2017 20:39
PMCID: PMC54772
Related URLs:
URI: http://repository.cshl.edu/id/eprint/32270

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