A structural biology perspective on NMDA receptor pharmacology and function

Regan, Michael C., Romero-Hernandez, Annabel, Furukawa, Hiro (2015) A structural biology perspective on NMDA receptor pharmacology and function. Current Opinion in Structural Biology, 33. pp. 68-75. ISSN 0959-440X

URL: http://www.ncbi.nlm.nih.gov/pubmed/26282925
DOI: 10.1016/j.sbi.2015.07.012

Abstract

N-methyld-aspartate receptors (NMDARs) belong to the large family of ionotropic glutamate receptors (iGluRs), which are critically involved in basic brain functions as well as multiple neurological diseases and disorders. The NMDARs are large heterotetrameric membrane protein complexes. The extensive extracellular domains recognize neurotransmitter ligands and allosteric compounds and translate the binding information to regulate activity of the transmembrane ion channel. Here, we review recent advances in the structural biology of NMDARs with a focus on pharmacology and function. Structural analysis of the isolated extracellular domains in combination with the intact heterotetrameric NMDAR structure provides important insights into how this sophisticated ligand-gated ion channel may function.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > NMDA receptor
structural biology
CSHL Authors:
Communities: CSHL labs > Furukawa lab
Watson School > Publications
Stanley Institute for Cognitive Genomics
Depositing User: Matt Covey
Date Deposited: 24 Aug 2015 15:10
Last Modified: 05 Jan 2017 21:58
PMCID: PMC4641752
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31706

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