A developmental cell-type switch in cortical interneurons leads to a selective defect in cortical oscillations

Takada, N., Pi, H. J., Sousa, V. H., Waters, J., Fishell, G., Kepecs, A., Osten, P. (2014) A developmental cell-type switch in cortical interneurons leads to a selective defect in cortical oscillations. Nature Communications, 5. p. 5333. ISSN 2041-1723

URL: http://www.ncbi.nlm.nih.gov/pubmed/25354876
DOI: 10.1038/ncomms6333

Abstract

The cellular diversity of interneurons in the neocortex is thought to reflect subtype-specific roles of cortical inhibition. Here we ask whether perturbations to two subtypes-parvalbumin-positive (PV+) and somatostatin-positive (SST+) interneurons-can be compensated for with respect to their contributions to cortical development. We use a genetic cell fate switch to delete both PV+ and SST+ interneurons selectively in cortical layers 2-4 without numerically changing the total interneuron population. This manipulation is compensated for at the level of synaptic currents and receptive fields (RFs) in the somatosensory cortex. By contrast, we identify a deficit in inhibitory synchronization in vitro and a large reduction in cortical gamma oscillations in vivo. This reveals that, while the roles of inhibition in establishing cortical inhibitory/excitatory balance and RFs can be subserved by multiple interneuron subtypes, gamma oscillations depend on cellular properties that cannot be compensated for-likely, the fast signalling properties of PV+ interneurons.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons

organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons
CSHL Authors:
Communities: CSHL labs > Kepecs lab
CSHL labs > Osten lab
Depositing User: Matt Covey
Date Deposited: 07 Nov 2014 17:26
Last Modified: 27 Apr 2015 14:59
PMCID: PMC4220465
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30900

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