The transcription factor Foxo1 controls central-memory CD8+ T cell responses to infection

Kim, M. V., Ouyang, W., Liao, W., Zhang, M. Q., Li, M. O. (August 2013) The transcription factor Foxo1 controls central-memory CD8+ T cell responses to infection. Immunity, 39 (2). pp. 286-97. ISSN 1074-7613

URL: http://www.ncbi.nlm.nih.gov/pubmed/23932570
DOI: 10.1016/j.immuni.2013.07.013

Abstract

Memory T cells protect hosts from pathogen reinfection, but how these cells emerge from a pool of antigen-experienced T cells is unclear. Here, we show that mice lacking the transcription factor Foxo1 in activated CD8+ T cells have defective secondary, but not primary, responses to Listeria monocytogenes infection. Compared to short-lived effector T cells, memory-precursor T cells expressed higher amounts of Foxo1, which promoted their generation and maintenance. Chromatin immunoprecipitation sequencing revealed the transcription factor Tcf7 and the chemokine receptor Ccr7 as Foxo1-bound target genes, which have critical functions in central-memory T cell differentiation and trafficking. These findings demonstrate that Foxo1 is selectively incorporated into the genetic program that regulates memory CD8+ T cell responses to infection.

Item Type: Paper
Uncontrolled Keywords: Adoptive Transfer Animals Bone Marrow Cells CD8-Positive T-Lymphocytes/*immunology/metabolism Cell Differentiation Forkhead Transcription Factors/deficiency/genetics/*metabolism Green Fluorescent Proteins/genetics Immunologic Memory/*immunology Listeria monocytogenes/immunology Listeriosis/immunology Lymphocyte Activation/immunology Mice Mice, Inbred C57BL Mice, Transgenic Receptors, CCR7/*metabolism T Cell Transcription Factor 1/*metabolism
Subjects: diseases & disorders > Bacterial Infections
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells

organs, tissues, organelles, cell types and functions > cell types and functions > cell types > immune cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > immune cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > immune cell

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor
CSHL Authors:
Communities: CSHL labs > Atwal lab
Depositing User: Matt Covey
Date: 22 August 2013
Date Deposited: 07 Mar 2014 16:38
Last Modified: 14 Mar 2014 13:37
PMCID: PMC3809840
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29566

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