From circuit motifs to computations: mapping the behavioral repertoire of cortical interneurons

Hangya, B., Pi, H. J., Kvitsiani, D., Ranade, S. P., Kepecs, A. (February 2014) From circuit motifs to computations: mapping the behavioral repertoire of cortical interneurons. Current Opinion in Neurobiology, 26c. pp. 117-124. ISSN 0959-4388

URL: http://www.ncbi.nlm.nih.gov/pubmed/24508565
DOI: 10.1016/j.conb.2014.01.007

Abstract

The exquisite architecture of cortex incorporates a myriad of inhibitory interneuron types. Until recently, the dearth of techniques for cell type identification in awake animals has made it difficult to link interneuron activity with circuit function, computation and behavior. This situation has changed dramatically in recent years with the advent of novel tools for targeting genetically distinct interneuron types so their activity can be observed and manipulated. The association of different interneuron subtypes with specific circuit functions, such as gain modulation or disinhibition, is starting to reveal canonical circuit motifs conserved across neocortical regions. Moreover, it appears that some interneuron types are recruited at specific behavioral events and likely control the flow of information among and within brain areas at behavioral time scales. Based on these results we propose that interneuron function goes beyond network coordination and interneurons should be viewed as integral elements of cortical computations serving behavior.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > cerebral cortex
bioinformatics > computational biology
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons

organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
CSHL Authors:
Communities: CSHL labs > Kepecs lab
Depositing User: Matt Covey
Date: 4 February 2014
Date Deposited: 21 Feb 2014 21:34
Last Modified: 27 Apr 2015 15:15
PMCID: PMC4090079
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29543

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