Genetic analyses on DNA microarrays

Stein, L. D. (2001) Genetic analyses on DNA microarrays. Curr Protoc Hum Genet, Chapte. Unit 11 .01.

URL: http://www.ncbi.nlm.nih.gov/pubmed/18428244
DOI: 10.1002/0471142905.hg1101s24

Abstract

A great stir has coursed through the genetics community with the advent in 1996 of "chip technologies," a series of related techniques that allow DNA hybridization-based studies to be performed with unprecedented speed and parallelism. All chip technologies have in common a microarray, a small glass chip approximately one square centimeter in area, to which nucleotide sequences are bound. Fluorescently labeled nucleic acids are hybridized to the microarray and imaged with a laser scanner or fluorescence microscope. This unit offers an overview of the two dominant technologies, cDNA microarrays and oligonucleotide chips. It concludes with a discussion regarding how well microarrays perform real-world expression analysis.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > Mapping and Rendering > Micro Array Data Rendering
bioinformatics > genomics and proteomics > analysis and processing > microarray gene expression processing
CSHL Authors:
Communities: CSHL labs > Stein lab
Depositing User: Matt Covey
Date Deposited: 16 Jan 2014 17:28
Last Modified: 16 Jan 2014 17:28
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29309

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