Postsynaptic conversion of silent synapses during LTP affects synaptic gain and transmission dynamics

Poncer, J. C., Malinow, R. (October 2001) Postsynaptic conversion of silent synapses during LTP affects synaptic gain and transmission dynamics. Nature Neuroscience, 4 (10). pp. 989-996. ISSN 1097-6256

URL: http://www.ncbi.nlm.nih.gov/pubmed/11544481
DOI: 10.1038/nn719

Abstract

Synaptic transmission relies on both the gain and the dynamics of synapses. Activity-dependent changes in synaptic gain are well-documented at excitatory synapses and may represent a substrate for information storage in the brain. Here we examine the mechanisms of changes in transmission dynamics at excitatory synapses. We show that paired-pulse ratios (PPRs) of AMPAR and NMDAR EPSCs onto dentate gyrus granule cells are often different; this difference is reduced during LTP, reflecting PPR changes of AMPAR but not NMDAR EPSCs. Presynaptic manipulations, however, produce parallel changes in AMPAR and NMDAR EPSCs. LTP at these synapses reflects a reduction in the proportion of silent synapses lacking functional AMPARs. Changes in PPR during LTP therefore reflect the initial difference between PPRs of silent and functional synapses. Functional conversion of silent synapses permits postsynaptic sampling from additional release sites and thereby affects the dynamics and gain of signals conveyed between neurons.

Item Type: Paper
Uncontrolled Keywords: LONG-TERM POTENTIATION PAIRED-PULSE FACILITATION NEOCORTICAL PYRAMIDAL NEURONS NEUROTRANSMITTER RELEASE TRANSMITTER RELEASE GLUTAMATE RELEASE HIPPOCAMPAL SLICE AMPA RECEPTORS NMDA RECEPTORS DENTATE GYRUS
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > synaptic plasticity
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > synaptic transmission
CSHL Authors:
Communities: CSHL labs > Malinow lab
Depositing User: Matt Covey
Date: October 2001
Date Deposited: 16 Jan 2014 17:43
Last Modified: 16 Jan 2014 17:43
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29287

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