Losada, A., Hirano, T.
(October 2001)
Shaping the metaphase chromosome: coordination of cohesion and condensation.
Bioessays, 23 (10).
pp. 924-935.
ISSN 0265-9247
Abstract
Recent progress in our understanding of mitotic chromosome dynamics has been accelerated by the identification of two essential protein complexes, cohesin and condensin. Cohesin is required for holding sister chromatids (duplicated chromosomes) together from S phase until the metaphase-to-anaphase transition. Condensin is a central player in chromosome condensation, a process that initiates at the onset of mitosis. The main focus of this review is to discuss how the mitotic metaphase chromosome is assembled and shaped by a precise balance between the cohesion and condensation machineries. We argue that, in different eukaryotic organisms, the balance of cohesion and condensation is adjusted in such a way that the size and shape of the resulting chromosomes are best suited for their accurate segregation.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
SISTER-CHROMATID COHESION
BUDDING YEAST
SACCHAROMYCES-CEREVISIAE
PROTEIN COMPLEXES
DNA-REPLICATION
13S CONDENSIN
HISTONE H3
STRUCTURAL MAINTENANCE
PRECOCIOUS SEPARATION
CONSERVED PROTEIN |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > metaphase |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Hirano lab |
| Depositing User: |
Matt Covey
|
| Date: |
October 2001 |
| Date Deposited: |
17 Jan 2014 21:38 |
| Last Modified: |
17 Jan 2014 21:38 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/29266 |
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