Dynamin assembly strategies and adaptor proteins in mitochondrial fission

Bui, H. T., Shaw, J. M. (2013) Dynamin assembly strategies and adaptor proteins in mitochondrial fission. Current Biology, 23 (19). R891-R899. ISSN 09609822 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/24112988
DOI: 10.1016/j.cub.2013.08.040

Abstract

Mitochondrial fission is mediated by a dynamin-related GTPase that assembles at constricted sites on the organelle. The mechanism of action of this GTPase in fission is related to that of classical dynamin, which severs the necks of clathrin-coated pits at the plasma membrane. The scale of these membrane remodeling events differs by an order of magnitude, however, and structural studies have revealed variations in the assembly properties of classical and mitochondrial dynamins that accommodate these differences. Despite this progress, structural and mechanistic models have not yet incorporated a growing number of adaptor proteins that are required for the membrane recruitment and function of mitochondrial dynamins. Here, we review the structure and assembly properties of the yeast and mammalian mitochondrial dynamins and discuss what is known about the activities of their adaptor proteins. © 2013 Elsevier Ltd.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > GTPase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
organs, tissues, organelles, cell types and functions > organelles, types and functions > mitochondria
organs, tissues, organelles, cell types and functions > organelles, types and functions
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
CSHL Authors:
Communities: CSHL labs > Jackson lab
Depositing User: Matt Covey
Date Deposited: 05 Nov 2013 22:04
Last Modified: 05 Nov 2013 22:04
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28830

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