Contrast dependence and differential contributions from somatostatin- and parvalbumin-expressing neurons to spatial integration in mouse v1

Nienborg, H., Hasenstaub, A., Nauhaus, I., Taniguchi, H., Huang, Z. J., Callaway, E. M. (2013) Contrast dependence and differential contributions from somatostatin- and parvalbumin-expressing neurons to spatial integration in mouse v1. Journal of Neuroscience, 33 (27). pp. 11145-54. ISSN 0270-6474

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URL: http://www.ncbi.nlm.nih.gov/pubmed/23825418
DOI: 10.1523/jneurosci.5320-12.2013

Abstract

A characteristic feature in the primary visual cortex is that visual responses are suppressed as a stimulus extends beyond the classical receptive field. Here, we examined the role of inhibitory neurons expressing somatostatin (SOM(+)) or parvalbumin (PV(+)) on surround suppression and preferred receptive field size. We recorded multichannel extracellular activity in V1 of transgenic mice expressing channelrhodopsin in SOM(+) neurons or PV(+) neurons. Preferred size and surround suppression were measured using drifting square-wave gratings of varying radii and at two contrasts. Consistent with findings in primates, we found that the preferred size was larger for lower contrasts across all cortical depths, whereas the suppression index (SI) showed a trend to decrease with contrast. We then examined the effect of these metrics on units that were suppressed by photoactivation of either SOM(+) or PV(+) neurons. When activating SOM(+) neurons, we found a significant increase in SI at cortical depths >400 mum, whereas activating PV(+) neurons caused a trend toward lower SIs regardless of cortical depth. Conversely, activating PV(+) neurons significantly increased preferred size across all cortical depths, similar to lowering contrast, whereas activating SOM(+) neurons had no systematic effect on preferred size across all depths. These data suggest that SOM(+) and PV(+) neurons contribute differently to spatial integration. Our findings are compatible with the notion that SOM(+) neurons mediate surround suppression, particularly in deeper cortex, whereas PV(+) activation decreases the drive of the input to cortex and therefore resembles the effects on spatial integration of lowering contrast.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits

organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons

organs, tissues, organelles, cell types and functions > tissues types and functions
organs, tissues, organelles, cell types and functions > tissues types and functions > visual cortex
CSHL Authors:
Communities: CSHL labs > Huang lab
Depositing User: Matt Covey
Date Deposited: 19 Jul 2013 15:18
Last Modified: 07 Apr 2015 15:51
PMCID: PMC3718383
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28445

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