Infiltration and migration of c-fms+ myeloid cells in the tumor microenvironment.

Egeblad, M., Ewald, A. J., Askautrud, H. A., Truitt, M. L., Welm, B. E., Bainbridge, E., Peeters, G., Krummel, M. F., Werb, Z. (2008) Infiltration and migration of c-fms+ myeloid cells in the tumor microenvironment. [Video]

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Abstract

Infiltration and migration of c-fms+ myeloid cells in the tumor microenvironment. c-fms+ myeloid cells migrate at the border of a late carcinoma, whereas migration within the tumor mass mostly occurs along blood vessels and in stromal patches. c-fms+ cells (green) are seen migrating at the border of the carcinoma (blue) in the bottom of the field, along c-fms+-dense tracks that penetrate into the tumor mass and along blood vessels inside the mass in an MMTV-PyMT;ACTB-ECFP;c-fms-EGFP mouse. Few of the c-fms+ cells that have infiltrated the carcinoma mass migrate. c-fms+ cells are also seen flowing through blood vessels inside the lesion (black areas on the surrounding background of blue cancer cells). From Egeblad et al. (2008) Dis. Model. Mech., 1 155-167.

Item Type: Video
Subjects: diseases & disorders > cancer
diseases & disorders
Investigative techniques and equipment
Investigative techniques and equipment > microscopy > flourescence microscopy
Investigative techniques and equipment > microscopy > immunoflourescence microscopy
Investigative techniques and equipment > microscopy
CSHL Authors:
Communities: CSHL labs > Egeblad lab
Depositing User: Matt Covey
Date: 2008
Date Deposited: 26 Apr 2013 15:31
Last Modified: 26 Apr 2013 15:31
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28259

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