Organization and expression of the left third of the genome of adenovirus

Lewis, J. B., Esche, H., Smart, J. E., Stillman, B. W., Harter, M. L., Mathews, M. B. (1979) Organization and expression of the left third of the genome of adenovirus. Cold Spring Harb Symp Quant Biol, 44 (1). pp. 493-508.

URL: http://www.ncbi.nlm.nih.gov/pubmed/6933045
DOI: 10.1101/SQB.1980.044.01.052

Abstract

The regions of the human adenoviral genome associated with the process of oncogenesis have been identified using several approaches. Analysis of the viral DNAs contained in different lines of cells transformed by virus has demonstrated that retention of the leftmost 14% of the genome is sufficient for the maintenance of the transformed growth properties of these cells (Gallimore et al. 1974). The adenoviral mRNAs expressed in transformed cell lines are similar to those expressed from these DNA sequences during the early phase of the productive infection (Flint et al. 1975). The left end of the viral DNA contains at least two genes necessary for transformation, since two complementation groups of host-range mutants that map within this region (Frost and Williams 1978) are both defective for transformation (Graham et al. 1978). Transfection of cells with fragments of viral DNA has provided a direct means of determining the minimum amount of viral...

Item Type: Paper
Uncontrolled Keywords: messenger rna radioisotope adenovirus animal experiment gene expression heredity protein synthesis Adenoviruses, Human Chromosome Mapping Cycloheximide DNA, Viral Gene Expression Regulation Genes Genes, Viral RNA, Messenger Viral Proteins Virus Replication
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
organism description > virus > adeno associated virus
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mRNA dynamics
organism description > virus
CSHL Authors:
Communities: CSHL labs > Stillman lab
Highlight: Stillman, Bruce W.
Depositing User: Matt Covey
Date Deposited: 08 Mar 2013 18:31
Last Modified: 20 Jun 2017 20:47
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27735

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