The spatial and temporal origin of chandelier cells in mouse neocortex

Taniguchi, H., Lu, J., Huang, Z. J. (2013) The spatial and temporal origin of chandelier cells in mouse neocortex. Science, 339 (6115). pp. 70-4. ISSN 1095-9203 (Electronic)0036-8075 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/23180771
DOI: 10.1126/science.1227622

Abstract

Diverse gamma-aminobutyric acid-releasing interneurons regulate the functional organization of cortical circuits and derive from multiple embryonic sources. It remains unclear to what extent embryonic origin influences interneuron specification and cortical integration because of difficulties in tracking defined cell types. Here, we followed the developmental trajectory of chandelier cells (ChCs), the most distinct interneurons that innervate the axon initial segment of pyramidal neurons and control action potential initiation. ChCs mainly derive from the ventral germinal zone of the lateral ventricle during late gestation and require the homeodomain protein Nkx2.1 for their specification. They migrate with stereotyped routes and schedule and achieve specific laminar distribution in the cortex. The developmental specification of this bona fide interneuron type likely contributes to the assembly of a cortical circuit motif.

Item Type: Paper
Uncontrolled Keywords: Animals Cell Lineage Female Interneurons/metabolism/ physiology Lateral Ventricles/cytology/embryology Mice Mice, Mutant Strains Neocortex/ cytology/embryology Neural Stem Cells/metabolism Nuclear Proteins/genetics/metabolism Pyramidal Cells/metabolism/ physiology Transcription Factors/genetics/metabolism gamma-Aminobutyric Acid/metabolism
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > cerebral cortex
organs, tissues, organelles, cell types and functions
organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:
Communities: CSHL labs > Huang lab
CSHL Post Doctoral Fellows
Depositing User: Matt Covey
Date Deposited: 11 Feb 2013 19:49
Last Modified: 07 Apr 2015 15:54
PMCID: PMC4017638
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27228

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