A primate virus generates transformed human cells by fusion

Duelli, D. M., Hearn, S., Myers, M. P., Lazebnik, Y. (November 2005) A primate virus generates transformed human cells by fusion. J Cell Biol, 171 (3). pp. 493-503. ISSN 0021-9525 (Print)

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URL: https://www.ncbi.nlm.nih.gov/pubmed/16275753
DOI: 10.1083/jcb.200507069

Abstract

A model that explains both the origin and sporadic nature of cancer argues that cancer cells are a chance result of events that cause genomic and epigenetic variability. The prevailing view is that these events are mutations that affect chromosome segregation or stability. However, genomic and epigenetic variability is also triggered by cell fusion, which is often caused by viruses. Yet, cells fused by viruses are considered harmless because they die. We provide evidence that a primate virus uses both viral and exosomal proteins involved in cell fusion to produce transformed proliferating human cells. Although normal cells indeed fail to proliferate after fusion, expression of an oncogene or a mutated tumor suppressor p53 in just one of the fusion partners is sufficient to produce heterogeneous progeny. We also show that this virus can produce viable oncogenically transformed cells by fusing cells that are otherwise destined to die. Therefore, we argue that viruses can contribute to carcinogenesis by fusing cells.

Item Type: Paper
Uncontrolled Keywords: Animals Cell Fusion Cell Line Cell Survival Cell Transformation Neoplastic Cell Transformation Viral Genes p53 Humans Hybrid Cells Mason-Pfizer monkey virus genetics physiology Mutation Oncogenes
Subjects: diseases & disorders > cancer
Investigative techniques and equipment > cell fusion
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > epigenetics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > epigenetics
CSHL Authors:
Communities: CSHL labs > Labeznik lab
Depositing User: CSHL Librarian
Date: 7 November 2005
Date Deposited: 13 Jan 2012 16:17
Last Modified: 03 May 2018 14:56
PMCID: PMC2171256
Related URLs:
URI: http://repository.cshl.edu/id/eprint/22557

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