Primary cilia regulate proliferation of amplifying progenitors in adult hippocampus: implications for learning and memory

Amador-Arjona, A., Elliott, J., Miller, A., Ginbey, A., Pazour, G. J., Enikolopov, G. N., Roberts, A. J., Terskikh, A. V. (July 2011) Primary cilia regulate proliferation of amplifying progenitors in adult hippocampus: implications for learning and memory. J Neurosci, 31 (27). pp. 9933-44. ISSN 1529-2401 (Electronic) 0270-6474 (Linking)

[img]
Preview
PDF (Paper)
Enikolopov J Neurosci 2011.pdf - Published Version

Download (6Mb) | Preview
URL: https://www.ncbi.nlm.nih.gov/pubmed/21734285
DOI: 10.1523/jneurosci.1062-11.2011

Abstract

Integration of new neurons into the adult hippocampus has been linked to specific types of learning. Primary cilia were found to be required for the formation of adult neural stem cells (NSCs) in the hippocampal dentate gyrus during development. However, the requirement of cilia in maintenance of adult NSCs is unknown. We developed a genetic mouse model in which fetal/perinatal brain development is unaffected, but adult hippocampal neurogenesis is constantly reduced by conditional ablation of primary cilia in adult GFAP(+) neural stem/progenitor cells. We found that this approach specifically reduces the number of hippocampal amplifying progenitors (also called type 2a cells) without affecting the number of radial NSCs (or type 1 cells). Constant reduction of adult hippocampal neurogenesis produced a delay rather than a permanent deficiency in spatial learning without affecting the retention of long-term memories. Decreased neurogenesis also altered spatial novelty recognition and hippocampus-independent cue conditioning. Here, we propose that adult hippocampal newborn neurons increase the efficiency of generating the new representations of spatial memories and that reduction of adult hippocampal neurogenesis may be biased toward cue-based strategies. This novel mouse model provides evidences that cognitive deficits associated with ciliary defects (ciliopathies) might be, in part, mediated by the deficiency of primary cilia in adult hippocampal stem/progenitor cells.

Item Type: Paper
Subjects: organism description > animal > developmental stage > fetal
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
organism description > animal > mammal > rodent > mouse
therapies > stem cells
CSHL Authors:
Communities: CSHL labs > Enikopolov lab
Depositing User: CSHL Librarian
Date: 6 July 2011
Date Deposited: 26 Oct 2011 18:43
Last Modified: 06 Nov 2017 20:49
PMCID: PMC3758574
Related URLs:
URI: http://repository.cshl.edu/id/eprint/15598

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving