Locus coeruleus noradrenergic neurons have diverse activity patterns across species and biological context

Kelberman, Michael A, Rodberg, Ellen, Munn, Brandon R, Arabzadeh, Ehsan, Bair-Marshall, Chloe J, Berridge, Craig W, Berrocoso, Esther, Breton-Provencher, Vincent, Chandler, Daniel J, Che, Alicia, Davy, Oscar, Devilbiss, David M, Downs, Anthony M, Drummond, Gabrielle, Dvorkin, Roman, Fazlali, Zeinab, Froemke, Robert C, Glennon, Erin, Gold, Joshua I, Ito, Hiroki, Jiang, Xiaolong, Johansen, Joshua P, Kaye, Alfred P, Kim, Jenny R, Kuo, Chao-Cheng, Liu, Rong-Jian, Liu, Yang, Llorca-Torralba, Meritxell, McCall, Jordan G, McElligott, Zoe A, McKinney, Andrew M, Miguelez, Cristina, Min, Ming-Yuan, Nowlan, Alexandra C, Omrani, Mohsen, Poe, Gina R, Pickering, Anthony Edward, Ranjbar-Slamloo, Yadollah, Razquin, Jone, Rodenkirch, Charles, Sales, Anna C, Satyasambit, Rath, Shea, Stephen D, Sur, Mriganka, Tkaczynski, John Arthur, Torres-Sanchez, Sonia, Uematsu, Akira, Vazquez, Chayla R, Vreven, Amelien, Wang, Qi, Waterhouse, Barry D, Yang, Hsiu-Wen, Yang, Jen-Hau, Zhao, Liping, Zouridis, Ioannis S, Shine, James M, Weinshenker, David, Vazey, Elena, Totah, Nelson K (October 2026) Locus coeruleus noradrenergic neurons have diverse activity patterns across species and biological context. Cell reports, 45 (11). p. 118210. ISSN 2639-1856

PDF 10.1016.j.celrep.2026.118210.pdf - Published Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (7MB)

Abstract

The locus coeruleus (LC) brainstem cell group is evolutionarily conserved across vertebrates and influences both mind (cognition) and body (cardiorespiratory, metabolic, and immune functions) via two-putatively distinct-spontaneous activity patterns. Yet, the degree to which spontaneous LC firing rates and patterns are homogeneous across species has never been assessed due to inherently limited sample sizes. To remedy this, we pooled cross-species data from 20 laboratories to show that firing rates differ across species and are modulated by sex, age, and type of in vitro or in vivo preparation. Contrary to the prevailing dual-mode firing pattern schema, we observed patterns spread across a low-dimensional manifold, with subregions enriched for specific biological factors and neurodegenerative disease models. Our findings show considerable diversity in an ancestral vertebrate neuromodulatory system.

Item Type:	Paper
Subjects:	organs, tissues, organelles, cell types and functions > tissues types and functions > locus coeruleus organs, tissues, organelles, cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Dvorkin, Roman Shea, Stephen D.
Communities:	CSHL labs > Shea lab CSHL Post Doctoral Fellows
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	29 October 2026
Date Deposited:	06 Nov 2026 13:12
Last Modified:	06 Nov 2026 13:12
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/42362

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