Namba, Hiroe, Mir, Sana, Groce, Erin L, Alexander, Katherine A (April 2026) Nuclear speckles: a fundamental layer of gene regulation. Trends in Cell Biology. S0962-8924(26)00059. ISSN 0962-8924
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Abstract
Within the cell nucleus, non-DNA structures called nuclear bodies interact with chromatin to regulate gene expression and organize our genetic material. Among nuclear bodies, nuclear speckles are prominent. They interact with broad genomic regions, serve as major gene-activating structures, and are implicated in viral infection, cancer, neurodegeneration, stress response, and development. Advances that integrate genomics with imaging are leading to a deeper understanding of how nuclear speckles fit into our current knowledge of chromatin biology, genome organization, and the central dogma of biology. Collectively, these recent studies emphasize nuclear speckles as key gene regulatory structures within the cell nucleus, offering new perspectives on how gene expression dysregulation is linked to disease.
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > nuclear speckles |
| CSHL Authors: | |
| Communities: | CSHL labs > Dos Santos lab CSHL labs > Alexander lab School of Biological Sciences > Publications CSHL Post Doctoral Fellows |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 30 April 2026 |
| Date Deposited: | 04 Sep 2026 13:22 |
| Last Modified: | 04 Sep 2026 13:22 |
| PMCID: | PMC13155460 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/42305 |
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