CAR T targets: AI takes the wheel

Amor, Corina (June 2026) CAR T targets: AI takes the wheel. Cell, 189 (13). pp. 3847-3848. ISSN 0092-8674

URL: https://www.ncbi.nlm.nih.gov/pubmed/42349381

DOI: 10.1016/j.cell.2026.06.003

Abstract

Identifying safe and effective targets remains a major bottleneck for CAR T cell therapies. In this issue of Cell, Baker and colleagues developed a large language model (LLM)-assisted scoring framework to streamline this process and as a result identified and validated glycoprotein non-metastatic melanoma protein B (GPNMB) as a candidate chimeric antigen receptor (CAR) T target across melanoma, leukemia, and colorectal cancer.

Item Type:	Paper
Subjects:	organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions
CSHL Authors:	Amor, Corina
Communities:	CSHL labs > Amor lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	25 June 2026
Date Deposited:	26 Jun 2026 12:16
Last Modified:	26 Jun 2026 12:16
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/42231

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