Li, Yujia, Borniger, Jeremy C (June 2026) C1QL1: A Long-range Signal Orchestrating Glioma Connectivity and Synaptic Remodeling. Cancer Discovery, 16 (6). pp. 1047-1049. ISSN 2159-8274
Abstract
Glioblastoma (GBM) cells secrete C1QL1, which binds BAI3 on nearby neurons and tumor cells to activate RAC1, promoting tumor microtube growth, malignant synapse formation, and remodeling of normal synapses. Blocking RAC1 with a targeted inhibitor disrupts this process and may help prevent GBM recurrence. See related article by Ding et al., p. 1176.
| Item Type: | Paper |
|---|---|
| Subjects: | organs, tissues, organelles, cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions > signal transduction organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse organs, tissues, organelles, cell types and functions > tissues types and functions |
| CSHL Authors: | |
| Communities: | CSHL labs > Borniger lab CSHL Post Doctoral Fellows |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 1 June 2026 |
| Date Deposited: | 05 Jun 2026 12:08 |
| Last Modified: | 05 Jun 2026 12:08 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/42218 |
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