Two's company: Astrocytes and microglia team up to refine developing circuits

Cheadle, Lucas (April 2026) Two's company: Astrocytes and microglia team up to refine developing circuits. Neuron, 114 (8). pp. 1326-1328. ISSN 0896-6273

URL: https://www.ncbi.nlm.nih.gov/pubmed/41990727

DOI: 10.1016/j.neuron.2026.03.024

Abstract

In this issue of Neuron, Ramirez et al. identify a mechanism through which astrocytes and microglia interact to refine developing thalamocortical circuits. The C-terminal fragment of astrocyte-derived Hevin binds microglial TLR4, inducing TLR2 expression and increasing synaptic phagocytosis. This astrocyte-microglial crosstalk is essential for the refinement of synapses in the developing brain.

Item Type:	Paper
Subjects:	organs, tissues, organelles, cell types and functions > cell types and functions > cell types > astrocytes organs, tissues, organelles, cell types and functions > cell types and functions > cell types > astrocytes organs, tissues, organelles, cell types and functions > cell types and functions > cell types > astrocytes organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types > microglia organs, tissues, organelles, cell types and functions > cell types and functions > cell types > microglia organs, tissues, organelles, cell types and functions > cell types and functions > cell types > microglia organs, tissues, organelles, cell types and functions
CSHL Authors:	Cheadle, Lucas
Communities:	CSHL labs > Cheadle lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	15 April 2026
Date Deposited:	20 Apr 2026 12:23
Last Modified:	20 Apr 2026 12:23
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/42159

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