Stimulus-Driven Population Activity Patterns in Macaque Primary Visual Cortex

Cowley, Benjamin R, Smith, Matthew A, Kohn, Adam, Yu, Byron M (December 2016) Stimulus-Driven Population Activity Patterns in Macaque Primary Visual Cortex. PLoS Computational Biology, 12 (12). e1005185. ISSN 1553-734X

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Abstract

Dimensionality reduction has been applied in various brain areas to study the activity of populations of neurons. To interpret the outputs of dimensionality reduction, it is important to first understand its outputs for brain areas for which the relationship between the stimulus and neural response is well characterized. Here, we applied principal component analysis (PCA) to trial-averaged neural responses in macaque primary visual cortex (V1) to study two fundamental, population-level questions. First, we characterized how neural complexity relates to stimulus complexity, where complexity is measured using relative comparisons of dimensionality. Second, we assessed the extent to which responses to different stimuli occupy similar dimensions of the population activity space using a novel statistical method. For comparison, we performed the same dimensionality reduction analyses on the activity of a recently-proposed V1 receptive field model and a deep convolutional neural network. Our results show that the dimensionality of the population response changes systematically with alterations in the properties and complexity of the visual stimulus.

Item Type:	Paper
Subjects:	bioinformatics organism description > animal organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions bioinformatics > computational biology organism description > animal > mammal organism description > animal > mammal > primates > monkey organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions organism description > animal > mammal > primates organs, tissues, organelles, cell types and functions > tissues types and functions organs, tissues, organelles, cell types and functions > tissues types and functions > visual cortex
CSHL Authors:	Cowley, Benjamin
Communities:	CSHL labs > Cowley lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	December 2016
Date Deposited:	22 May 2024 20:04
Last Modified:	22 May 2024 20:04
PMCID:	PMC5147778
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41560

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